M?

????1.??????2.?????????3.???????????4.?????????

?????X???????????????????????????????????o???X???
??
CT???????????????????????????
????k???
????????,???????

?
????(Osteogenesis imperfecatOI)???(fragilitas
ossium)VanDerHeeve??-????45/10?60%????15%20%???25%???1??????????????????????????????2030?????????????-?????????????????????515??????????????????????X????????
??????????4?()?????????a1(1)???mRNA??????2()?10%????????????????????????a1(1)????a???????3()...

??1??6???67????1?2?202?6???18?2??1??2??1?2?3???18-22?????????32?2832 ? ?23???30???
??   2010-02-03 09:59 ???????


???   2010-02-03 10:12 ?????????????z????????
?????????
??????????????????????????1625?????54%????44%??2.5
?????...

????
?24????18-24??
??18????? ??? ?
?????????? ?????
??????????????30
??? ????? ? ????
?????
???????? ??????
??????????
????
??
?? ????

??