??

2

???????????????????????????????????????????????????????????????????????Cincnona????????????????1826???????1/5???????




?Quinine
??

??? DNA???DNA?? RNA????????????????????????????????????????????????????????????????????????????????????

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?????? 70????????????? l3???????T1/2? 8.5??????????(? 10)??? 15?24???????

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1?????? 1.8g??? 14??()?? 5- 10mg/kg( 500mg)??? 500ml?4??12?????????????????????0.48g?? 0.36g? 3 7?

2?????1?? 0.1 0.2g 2 31? 3 0.2 0.3g4 6?0.3 0.5g,7? 1...