?????

???B???????10,000??????????????BCR????B??BCR?????B????BCR???????BCRB????????B?????(????)

(?)B????

?B?????????????????(clone)????????????(memory cell)

???TH???M?MHC??????M????MHC??TH???M?MHC+????B?MHC??????TH???AgB???????

()?
????????????2000???????
??\"Y\"????????(FC)?(?)?????
()???
????...

????()???????????????? b` t????` ???????????. ?(??????)(???)?(SLE,????)???(?)????(??)????(?????)??? ??( AIDS)?

??????^?????????Y????Y????????X/Y????????????Y?????????X??????????????????????????????????

???
1B??
2T??
3?
4??
??
1??
1?
2??IBD
3?????
2??
3?
4???

5AIDS

?198265?????20??????????????????????????

????????20??3610????8500?????????2200??????? ?????????????????????????????????????????????
198165,???5.1982,???\"?\",??\"???(Acquired Immune Deficiency Syndrome),?AIDS
?1985???????5?