??????

???B???????10,000??????????????BCR????B??BCR?????B????BCR???????BCRB????????B?????(????)

(?)B????

?B?????????????????(clone)????????????(memory cell)

???TH???M?MHC??????M????MHC??TH???M?MHC+????B?MHC??????TH???AgB???????

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????????????2000???????
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2T??
3?
4??
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1??
2??IBD
3??????
2??
3?
4???
5AIDS

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??immunodeficiencydiseasesIDD????????.:???,???,?,???.????,????,?,??,??????,,??,????.?:,???,???,?.?:????,?????,??,,,????.????????.??,??????,????,??,???.????,???,?.???,??,?,??,?,T???.???????.???.?,,,??,?,?????.????,????.??????,???:1?,??????,??????.2,????????100~300??????????,?????100.3??,??,????????.4...