?????

???!,??????,??,,??,???,??,?,,?.????,,???,????,??,??,???.??,?????,??.??????????,??.
??   2010-03-21 12:51 ???????????CT??

???   2010-03-21 12:58 ????
?
????
1.??????
????90-300mg/d 0.6-1.2/d,? 600-1200mg/d?
????? 0.2-0.6/d,?0.2...

?????????????????????
?????
????,?????????1984??????????????????????260?7000???????120??80%?????3?????2002???800098.65%,?62.3%
??????,???????????????????????????1998????????????????????2001???????????2002?????????????
??????i???,??
?????1990?????????????????1994??????????1995?????...

? ??

????????????CT?????????
????????????????????????????

??(leukodystrophy)??????????????MLD???ALD??MNGIE?????Pelizaeus-Merzbacher??PKU???????Alexander?MRI????????????????????????????????????

???????????????????????????????1



???@?(dysmyelinating disease)???(demyelinating disease)??Canavan??(myelinolytic)???????

????????????????????????????????????...

???????????????????????????

????????????