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???

???CRF???
?(?)
    ?(GFR)8050ml/min(?CFR)?{(Scr)133177mol/L??????
?(?)
    ?(GFR) 5020ml/minScr186446mol/L)???????????????
(?)
    GFR 2010ml/minScr451707mol/L????????????????????
(????)
    GFR 10ml/minScr707mol/L

????????????????????????????????????????????
?????
?????????????????????????????30%?????????????????
??
??????????????????????25%-30%.????????
?
?20%~25%.???????????????????????
??
?65520%???????????????
????????????????????...

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?????????????(?) ??????
1????
?????????????????????????????????????????????????????1.010~1.020??280mOsm/(kg?H2O)???CRF???????????? ??
2??????
(1)??
???????????????V???????????????????????????????????????????????? ?????
(2)???
???????125(OH)2D3???????????????????????
??????????D-125(OH)2D3?????????...

??????

?
????

???1.????????6070%???????????renaltubularacidosis????????????????????
2.????Cl-?Na+?1020%???????????????????????????
3.???????????H+K+NH3?Na+????????????????????????????????

?????????

???

??acute renal failure ARF???R????????????????????
???
???
?????????
1????????????????
1???? 24?400ml??17ml??100ml24h??????????????1 020?2Ommo1L?????ARF??????????1.0101.012?40mmoIL????????????
2???????????????????????????????????????????????????????????????????????

3????????????????NPN???????...