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???????????????????????????1.0151.030 ???????????????????????1.0100.003?
?????????m?????????????????m??????????????????????+?????,??,????.????,??,???,.?,?,,?,???,????,??,???,??,?,???. ????????,????,???,???,??;30-40,?????,???X?,???,????,??????,????????,???.
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+???1???????????????????+)500mg/24??????2????????+++),?+?+++?????????+++++????+++++++
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?????????????(?) ??????
1????
?????????????????????????????????????????????????????1.010~1.020??280mOsm/(kg?H2O)???CRF???????????? ??
2??????
(1)??
???????????????V???????????????????????????????????????????????? ?????
(2)???
???????125(OH)2D3???????????????????????
??????????D-125(OH)2D3?????????...

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??????????????????????
??????????????????20:1???40??^
??
????40%~80%????????????????????????????????????????????
???
???????k???? ???????????90%????????????????????????????????????????
???
????????????1/4??200X????B??PH8.0??100
?
90%??????????????????17%~25%??
??
?????????????>0.42mmol...

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???CRF???
?(?)
    ?(GFR)8050ml/min(?CFR)?{(Scr)133177mol/L??????
?(?)
    ?(GFR) 5020ml/minScr186446mol/L)???????????????
(?)
    GFR 2010ml/minScr451707mol/L????????????????????
(????)
    GFR 10ml/minScr707mol/L

????????????????????????...

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??acute renal failure ARF???R????????????????????
???
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?????????
1????????????????
1???? 24?400ml??17ml??100ml24h??????????????1 020?2Ommo1L?????ARF??????????1.0101.012?40mmoIL????????????
2???????????????????????????????????????????????????????????????????????

3????????????????NPN???????...