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      ????????Lentiviruses??HIV-1HIV-2????100120nm????????RNA???reverse transcriptase?integrase?protease??????p17/18p24/25????gp120gp41???11-1gp120???gp41????

       HIV???CD4+T???????????CD4+T?????????
   ?CD4??????HIV?Th??-????HIV?gp120?CD4???????????????CD4?????HIV gp120???HIV???HIV???

??(acquired immuno deficiency syndromeAIDS)???(human immunodeficiency virusHIV)?????CD4 T??(T?)???????????...

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???B???????10,000??????????????BCR????B??BCR?????B????BCR???????BCRB????????B?????(????)

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?B?????????????????(clone)????????????(memory cell)

???TH???M?MHC??????M????MHC??TH???M?MHC+????B?MHC??????TH???AgB???????

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