????

????????
???????????.

?(???)?????????(??????)(???)?(SLE,????)???(?)????(??)????(?????)???
???????????????????d???????

???B???????10,000??????????????BCR????B??BCR?????B????BCR???????BCRB????????B?????(????)

(?)B????

?B?????????????????(clone)????????????(memory cell)

???TH???M?MHC??????M????MHC??TH???M?MHC+????B?MHC??????TH???AgB???????

()?
????????????2000???????
??\"Y\"????????(FC)?(?)?????
()???
????...

??????^?????????Y????Y????????X/Y????????????Y?????????X??????????????????????????????????

?????????????????????????????????
?,?.??.??,?.

?198265?????20??????????????????????????

????????20??3610????8500?????????2200??????? ?????????????????????????????????????????????
198165,???5.1982,???\"?\",??\"???(Acquired Immune Deficiency Syndrome),?AIDS
?1985???????5?